Urinary Proteomics in Diabetes and CKD

Urinary proteomics in diabetes and CKD.

Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal diseases were sought. For 305 individuals, biomarkers were defined and validated in blinded data sets using high-resolution capillary electrophoresis coupled with electrospray-ionization mass spectrometry. A panel of 40 biomarkers distinguished patients with diabetes from healthy individuals with 89% sensit...

Urinary creatinine and survival in CKD.

Low muscle mass is associated with risk of CKD progression, cardiovascular disease events, and mortality in avarietyof settings (1). It iswidelyhypothesized that these associations may be confounded by conditions associated with low muscle mass, including frailty, poor physical fitness, poor nutritional status, and greater comorbidity. However, lowmuscle is also hypothesized to worsen insulin r...

urinary proteomics in nephrotic syndrome

nephrotic syndrome is the commonest glomerular disease. typical symptoms could be proteinuria, low serum albumin and oedema. the mechanism of proteinuria in nephrotic syndrome is a defective glomerular filtration barrier. renal biopsy is the gold standard for diagnosis of nephrotic syndrome currently which is invasive and based on histopathological features, therefore it seems to be necessary to...

Renal Transplantation and Urinary Proteomics

CKD273, a New Proteomics Classifier Assessing CKD and Its Prognosis

National Kidney Foundation CKD staging has allowed uniformity in studies on CKD. However, early diagnosis and predicting progression to end stage renal disease are yet to be improved. Seventy six patients with different levels of CKD, including outpatients and dialysed patients were studied for transcriptome, metabolome and proteome description. High resolution urinary proteome analysis was bli...